MolNFT v1 · #171933 · protein + RNA
Non-specific dsrna recognition by wildtype H7N1 RNA-binding domain
6ZLC · Non-structural protein 1: “Non-specific dsrna recognition by wildtype H7N1 RNA-binding domain”. X-ray diffraction, 2 ligands (NO3, SO4), 3 pockets (best druggability 0.83). MolNFT v1 #171933 on GenesisL1: 3D structure, binding sites…
- PDB
- 6ZLC
- Type
- protein + RNA
- Length
- 187 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 1; RNA (5'- R(*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*C…
- UniProt
- Q1PST0
- Ligands
- NO3, SO4
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-structural protein 1 | protein | 77 | 79% helix, 0% strand | Q1PST0 |
| B | Non-structural protein 1 | protein | 72 | 83% helix, 0% strand | Q1PST0 |
| C, D | RNA (5'- R(*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*U)-3') | rna | 19 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.83 | 0.97 | 26 | empty |
| 2 | 50 | 0.67 | 0.97 | 16 | empty |
| 3 | 530 | 0.61 | 0.75 | 28 | NO3 |
Interfaces
6 interfaces between chains.
- A–B · 1268 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 889 Ų buried · 84 hydrogen bonds · nucleic-nucleic
- A–C · 425 Ų buried · 6 hydrogen bonds · protein-nucleic
- B–D · 387 Ų buried · 3 hydrogen bonds · protein-nucleic
- B–C · 339 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 6ZLC · Non-specific dsRNA recognition by wildtype H7N1 RNA-binding domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1PST0
- Elsewhere: RCSB PDB 6ZLC · PDBe 6ZLC · UniProt Q1PST0
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