MolNFT v1 · #171844 · protein
Topological model of the P2 virion baseplate in activated conformation (closed tal trimer)
6ZIG · Receptor binding protein: “Topological model of the P2 virion baseplate in activated conformation (closed tal trimer)”. Electron microscopy, 20 pockets (best druggability 0.55). MolNFT v1 #171844 on GenesisL1: 3D structure, binding…
- PDB
- 6ZIG
- Type
- protein
- Length
- 9,435 residues
- Chains
- 33
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor binding protein; Distal tail protein; Baseplate protein GP16
- UniProt
- Q71AW2, D3WAD3, D3KFX4
- Pockets
- 20 · best druggability 0.55
Structure
electron microscopy · 3 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R | Receptor binding protein | protein | 263 | 0% helix, 0% strand | Q71AW2 |
| S, T, U, V, W, X, 2, 3, 4, 5, 6, 7 | Distal tail protein | protein | 298 | 0% helix, 0% strand | D3WAD3 |
| Y, Z, 1 | Baseplate protein GP16 | protein | 375 | 0% helix, 0% strand | D3KFX4 |
Pockets
20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 321 | 0.55 | 0.73 | 70 | empty |
| 2 | 255 | 0.53 | 0.74 | 53 | empty |
| 3 | 234 | 0.52 | 0.74 | 50 | empty |
| 4 | 236 | 0.51 | 0.73 | 52 | empty |
| 5 | 202 | 0.49 | 0.74 | 50 | empty |
Interfaces
65 interfaces between chains.
- B–C · 575 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 575 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 573 Ų buried · 0 hydrogen bonds · protein-protein
- K–L · 571 Ų buried · 0 hydrogen bonds · protein-protein
- N–O · 570 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6ZIG · Topological model of the p2 virion baseplate in activated conformation (closed Tal trimer) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71AW2
- Every structure of UniProt D3WAD3
- Every structure of UniProt D3KFX4
- Elsewhere: RCSB PDB 6ZIG · PDBe 6ZIG · UniProt Q71AW2 · UniProt D3WAD3 · UniProt D3KFX4
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