MolNFT v1 · #171735 · protein
KEAP1 kelch domain bound to a small molecule inhibitor of the KEAP1- NRF2 protein-protein interaction
6ZEZ: “KEAP1 kelch domain bound to a small molecule inhibitor of the KEAP1- NRF2 protein-protein interaction”. X-ray diffraction, 1 ligand (QHH). MolNFT v1 #171735 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZEZ
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9Z2X8
- Ligands
- QHH
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 289 | — | Q9Z2X8 |
Ligands and binding sites
- QHH · 1-[3-[(1~{R},3~{S})-3-[(2~{S})-2-butylpyrrolidin-1-yl]carbonylcyclohexyl]phenyl]-5-cyclopropyl-pyrazole-4-carboxylic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6ZEZ · Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z2X8 · AlphaFold monomer V2.0 prediction for kelch-like ech-associated protein 1 (Q9Z2X8) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z2X8
- Elsewhere: RCSB PDB 6ZEZ · PDBe 6ZEZ · UniProt Q9Z2X8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.