MolNFT v1 · #171705 · protein + RNA
Structure of telomerase from candida albicans in complexe with twj fragment of telomeric RNA
6ZDU · Telomerase reverse transcriptase: “Structure of telomerase from candida albicans in complexe with twj fragment of telomeric RNA”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #171705 on GenesisL1: 3D structure…
- PDB
- 6ZDU
- Type
- protein + RNA
- Length
- 1,516 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase; Chains: C,D
- EC
- 2.7.7.49
- UniProt
- A0A1D8PEA0
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 693 | 49% helix, 11% strand | A0A1D8PEA0 |
| C, D | Chains: C,D | rna | 65 | — | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1056 | 0.79 | 0.81 | 67 | empty |
| 2 | 710 | 0.78 | 0.82 | 48 | empty |
| 3 | 471 | 0.75 | 0.83 | 59 | empty |
| 4 | 424 | 0.72 | 0.82 | 59 | empty |
| 5 | 420 | 0.67 | 0.79 | 48 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2470 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 2006 Ų buried · 45 hydrogen bonds · protein-nucleic
- B–D · 1985 Ų buried · 42 hydrogen bonds · protein-nucleic
- C–D · 951 Ų buried · 41 hydrogen bonds · nucleic-nucleic
Compared structures
- 6ZDU · Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1D8PEA0
- Elsewhere: RCSB PDB 6ZDU · PDBe 6ZDU · UniProt A0A1D8PEA0
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