MolNFT v1 · #171701 · protein + RNA
Structure of telomerase from candida tropicalis in complexe with twj fragment of telomeric RNA
6ZDP · Telomerase reverse transcriptase: “Structure of telomerase from candida tropicalis in complexe with twj fragment of telomeric RNA”. X-ray diffraction, 1 ligand (K), 16 pockets (best druggability 0.78). MolNFT v1 #171701 on…
- PDB
- 6ZDP
- Type
- protein + RNA
- Length
- 750 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase; Chains: B
- EC
- 2.7.7.49
- UniProt
- C5MCQ7
- Ligands
- K
- Pockets
- 16 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 683 | 48% helix, 12% strand | C5MCQ7 |
| B | Chains: B | rna | 67 | — | — |
Ligands and binding sites
- K · Potassium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 736 | 0.78 | 0.82 | 81 | empty |
| 2 | 82 | 0.65 | 0.90 | 17 | empty |
| 3 | 176 | 0.63 | 0.84 | 24 | empty |
| 4 | 468 | 0.62 | 0.76 | 25 | empty |
| 5 | 111 | 0.60 | 0.87 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1362 Ų buried · 22 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 11 modified (engineered).
Compared structures
- 6ZDP · Structure of telomerase from Candida Tropicalis in complexe with TWJ fragment of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C5MCQ7
- Elsewhere: RCSB PDB 6ZDP · PDBe 6ZDP · UniProt C5MCQ7
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