MolNFT v1 · #171688 · protein
Structure of apo telomerase from candida tropicalis
6ZD6 · Telomerase reverse transcriptase: “Structure of apo telomerase from candida tropicalis”. X-ray diffraction, 9 pockets (best druggability 0.80). MolNFT v1 #171688 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZD6
- Type
- protein
- Length
- 653 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase
- EC
- 2.7.7.49
- UniProt
- C5MCQ7
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 653 | 52% helix, 13% strand | C5MCQ7 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 888 | 0.80 | 0.83 | 96 | empty |
| 2 | 171 | 0.63 | 0.84 | 26 | empty |
| 3 | 296 | 0.62 | 0.80 | 31 | empty |
| 4 | 90 | 0.56 | 0.85 | 23 | empty |
| 5 | 96 | 0.51 | 0.83 | 19 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6ZD6 · Structure of apo telomerase from Candida Tropicalis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C5MCQ7
- Elsewhere: RCSB PDB 6ZD6 · PDBe 6ZD6 · UniProt C5MCQ7
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