MolNFT v1 · #171633 · protein
Plasmodium falciparum merozoite surface protein 1 dimer, conformation 2
6ZBL · Precursor of the major merozoite surface antigens: “Plasmodium falciparum merozoite surface protein 1 dimer, conformation 2”. Electron microscopy, 20 pockets (best druggability 0.75). MolNFT v1 #171633 on GenesisL1: 3D structure…
- PDB
- 6ZBL
- Type
- protein
- Length
- 2,326 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Precursor of the major merozoite surface antigens; Merozoite surface protein-1
- UniProt
- Q25922, M1VF06
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 2 distinct chains · 78% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Precursor of the major merozoite surface antigens | protein | 665 | 79% helix, 1% strand | Q25922 |
| B, D | Merozoite surface protein-1 | protein | 498 | 78% helix, 1% strand | M1VF06 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1010 | 0.75 | 0.77 | 100 | empty |
| 2 | 800 | 0.75 | 0.79 | 62 | empty |
| 3 | 1074 | 0.74 | 0.77 | 107 | empty |
| 4 | 1143 | 0.74 | 0.77 | 77 | empty |
| 5 | 76 | 0.73 | 0.96 | 22 | empty |
Interfaces
5 interfaces between chains.
- C–D · 5683 Ų buried · 32 hydrogen bonds · protein-protein
- A–B · 5668 Ų buried · 32 hydrogen bonds · protein-protein
- B–C · 671 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 671 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 303 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6ZBL · Plasmodium falciparum merozoite surface protein 1 dimer, conformation 2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q25922
- Every structure of UniProt M1VF06
- Elsewhere: RCSB PDB 6ZBL · PDBe 6ZBL · UniProt Q25922 · UniProt M1VF06
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