MolNFT v1 · #171628 · protein
Merozoite surface protein 1 (msp-1) from plasmodium falciparum, alternative conformation 4
6ZBG · Merozoite surface antigens: “Merozoite surface protein 1 (msp-1) from plasmodium falciparum, alternative conformation 4”. Electron microscopy, 19 pockets (best druggability 0.76). MolNFT v1 #171628 on GenesisL1: 3D structure…
- PDB
- 6ZBG
- Type
- protein
- Length
- 1,160 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Merozoite surface antigens; Merozoite surface protein-1; Merozoite surface protein 1
- UniProt
- Q25922, M1V901, M1VNZ6, C4PDY5
- Pockets
- 19 · best druggability 0.76
Structure
electron microscopy · 4 distinct chains · 79% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Merozoite surface antigens | protein | 562 | 78% helix, 1% strand | Q25922 |
| B | Merozoite surface antigens | protein | 112 | 76% helix, 1% strand | M1V901 |
| C | Merozoite surface protein-1 | protein | 285 | 77% helix, 1% strand | M1VNZ6 |
| D | Merozoite surface protein 1 | protein | 201 | 86% helix, 1% strand | C4PDY5 |
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1029 | 0.76 | 0.78 | 93 | empty |
| 2 | 146 | 0.64 | 0.86 | 31 | empty |
| 3 | 442 | 0.63 | 0.77 | 40 | empty |
| 4 | 386 | 0.62 | 0.77 | 48 | empty |
| 5 | 339 | 0.61 | 0.78 | 31 | empty |
Interfaces
5 interfaces between chains.
- B–C · 3006 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 2297 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 2235 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1488 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 998 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6ZBG · Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 4 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q25922
- Every structure of UniProt M1V901
- Every structure of UniProt M1VNZ6
- Every structure of UniProt C4PDY5
- Elsewhere: RCSB PDB 6ZBG · PDBe 6ZBG · UniProt Q25922 · UniProt M1V901 · UniProt M1VNZ6 · UniProt C4PDY5
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