MolNFT v1 · #171627 · protein
Merozoite surface protein 1 (msp-1) from plasmodium falciparum, alternative conformation 3
6ZBF · Merozoite surface antigens: “Merozoite surface protein 1 (msp-1) from plasmodium falciparum, alternative conformation 3”. Electron microscopy, 19 pockets (best druggability 0.75). MolNFT v1 #171627 on GenesisL1: 3D structure…
- PDB
- 6ZBF
- Type
- protein
- Length
- 1,156 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Merozoite surface antigens; Merozoite surface protein-1; Merozoite surface protein 1
- UniProt
- Q25922, M1V901, M1VNZ6, C4PDY5
- Pockets
- 19 · best druggability 0.75
Structure
electron microscopy · 4 distinct chains · 79% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Merozoite surface antigens | protein | 560 | 79% helix, 1% strand | Q25922 |
| B | Merozoite surface antigens | protein | 111 | 74% helix, 1% strand | M1V901 |
| C | Merozoite surface protein-1 | protein | 285 | 76% helix, 1% strand | M1VNZ6 |
| D | Merozoite surface protein 1 | protein | 200 | 86% helix, 1% strand | C4PDY5 |
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1096 | 0.75 | 0.78 | 112 | empty |
| 2 | 466 | 0.64 | 0.77 | 38 | empty |
| 3 | 339 | 0.62 | 0.78 | 29 | empty |
| 4 | 387 | 0.61 | 0.77 | 52 | empty |
| 5 | 240 | 0.58 | 0.79 | 25 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2993 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2280 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 2247 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 1539 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 1006 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6ZBF · Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 3 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q25922
- Every structure of UniProt M1V901
- Every structure of UniProt M1VNZ6
- Every structure of UniProt C4PDY5
- Elsewhere: RCSB PDB 6ZBF · PDBe 6ZBF · UniProt Q25922 · UniProt M1V901 · UniProt M1VNZ6 · UniProt C4PDY5
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