MolNFT v1 · #171514 · protein
Insulin analytical antibody oxi-005 Fab
6Z7X · Oxi-005 Fab light chain: “Insulin analytical antibody oxi-005 Fab”. X-ray diffraction, 4 pockets (best druggability 0.51). MolNFT v1 #171514 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Z7X
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Oxi-005 Fab light chain; Oxi-005 Fab heavy chain
- Pockets
- 4 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Oxi-005 Fab light chain | protein | 213 | 6% helix, 51% strand | — |
| B | Oxi-005 Fab heavy chain | protein | 219 | 7% helix, 50% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 278 | 0.51 | 0.74 | 43 | empty |
| 2 | 146 | 0.46 | 0.77 | 22 | empty |
| 3 | 75 | 0.42 | 0.80 | 22 | empty |
| 4 | 111 | 0.38 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1970 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6Z7X · Insulin analytical antibody OXI-005 Fab · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6Z7X · PDBe 6Z7X
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