MolNFT v1 · #171412 · protein

Cryoem structure of horse SODIUM/PROTON exchanger NHE9 in an inward- facing conformation

6Z3Y · SODIUM/HYDROGEN exchanger: “Cryoem structure of horse SODIUM/PROTON exchanger NHE9 in an inward- facing conformation”. Electron microscopy, 16 pockets (best druggability 0.83). MolNFT v1 #171412 on GenesisL1: 3D structure, binding…

PDB: 6Z3Y
Type: protein
Length: 771 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SODIUM/HYDROGEN exchanger
UniProt: F7B113
Pockets: 16 · best druggability 0.83

Structure

electron microscopy · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	SODIUM/HYDROGEN exchanger	protein	386	73% helix, 0% strand	F7B113
A	SODIUM/HYDROGEN exchanger	protein	385	73% helix, 0% strand	F7B113

Pockets

16 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1178	0.83	0.83	134	empty
2	905	0.76	0.79	68	empty
3	865	0.76	0.79	60	empty
4	61	0.72	0.98	17	empty
5	91	0.72	0.94	13	empty

Interfaces

1 interface between chains.

B–A · 1870 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6Z3Y · CryoEM structure of horse sodium/proton exchanger NHE9 in an inward-facing conformation · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F7B113
Elsewhere: RCSB PDB 6Z3Y · PDBe 6Z3Y · UniProt F7B113

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