MolNFT v1 · #171324 · protein
Salmonella acrb solubilised in the sma copolymer
6Z12 · Efflux pump membrane transporter: “Salmonella acrb solubilised in the sma copolymer”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #171324 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Z12
- Type
- protein
- Length
- 3,044 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Efflux pump membrane transporter
- UniProt
- A0A3U3J7F4
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 3 distinct chains · 52% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Efflux pump membrane transporter | protein | 1015 | 51% helix, 17% strand | A0A3U3J7F4 |
| B | Efflux pump membrane transporter | protein | 1019 | 53% helix, 17% strand | A0A3U3J7F4 |
| C | Efflux pump membrane transporter | protein | 1010 | 52% helix, 15% strand | A0A3U3J7F4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 814 | 0.86 | 0.89 | 96 | empty |
| 2 | 494 | 0.84 | 0.91 | 79 | empty |
| 3 | 448 | 0.83 | 0.90 | 83 | empty |
| 4 | 496 | 0.82 | 0.88 | 69 | empty |
| 5 | 397 | 0.81 | 0.90 | 64 | empty |
Interfaces
3 interfaces between chains.
- B–C · 3212 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 3142 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 3072 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 6Z12 · Salmonella AcrB solubilised in the SMA copolymer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3U3J7F4
- Elsewhere: RCSB PDB 6Z12 · PDBe 6Z12 · UniProt A0A3U3J7F4
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