MolNFT v1 · #171274 · protein

Zinc metalloprotease proa from native source

6YZE · Zinc metalloproteinase: “Zinc metalloprotease proa from native source”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.53). MolNFT v1 #171274 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6YZE
Type: protein
Length: 328 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc metalloproteinase
EC: 3.4.24.-
UniProt: P21347
Ligands: ZN
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Zinc metalloproteinase (EC 3.4.24.-)	protein	328	37% helix, 20% strand	P21347

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	157	0.53	0.80	24	empty
2	114	0.51	0.81	19	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6YZE · Zinc metalloprotease ProA from native source · the same entry in another collection · chain A against A, TM-score 1.00
P21347 · AlphaFold monomer V2.0 prediction for zinc metalloproteinase (P21347) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21347
Elsewhere: RCSB PDB 6YZE · PDBe 6YZE · UniProt P21347

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