MolNFT v1 · #171229 · protein

Structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1

6YXO · SWI/SNF complex subunit SMARCC1: “Structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1”. X-ray diffraction, 4 pockets (best druggability 0.75). MolNFT v1 #171229 on GenesisL1: 3D structure, binding sites…

PDB: 6YXO
Type: protein
Length: 540 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SWI/SNF complex subunit SMARCC1
UniProt: Q92922
Pockets: 4 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	SWI/SNF complex subunit SMARCC1	protein	270	46% helix, 14% strand	Q92922

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1187	0.75	0.78	85	empty
2	473	0.71	0.81	51	empty
3	452	0.70	0.81	52	empty
4	89	0.33	0.73	17	empty

Interfaces

1 interface between chains.

A–B · 574 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

6YXO · Structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1 · the same entry in another collection · chain A against A, TM-score 1.00
Q92922 · AlphaFold monomer V2.0 prediction for SWI/SNF complex subunit SMARCC1 (Q92922) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92922
Elsewhere: RCSB PDB 6YXO · PDBe 6YXO · UniProt Q92922

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