MolNFT v1 · #171157 · protein
Plpro-C111S with MISG15
6YVA · Replicase polyprotein 1A: “Plpro-C111S with MISG15”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.72). MolNFT v1 #171157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6YVA
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replicase polyprotein 1A; Ubiquitin-like protein ISG15
- EC
- 3.4.19.12, 3.4.22.-, 3.4.22.69
- UniProt
- P0DTC1, Q64339
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replicase polyprotein 1A (EC 3.4.19.12, 3.4.22.-, 3.4.22.69) | protein | 283 | 24% helix, 27% strand | P0DTC1 |
| C | Ubiquitin-like protein ISG15 | protein | 155 | 21% helix, 34% strand | Q64339 |
Ligands and binding sites
- ZN · Zinc ion · metal
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 747 | 0.72 | 0.78 | 81 | empty |
| 2 | 72 | 0.64 | 0.92 | 20 | empty |
| 3 | 196 | 0.56 | 0.80 | 20 | empty |
| 4 | 97 | 0.45 | 0.79 | 21 | empty |
| 5 | 90 | 0.40 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–C · 1354 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTC1
- Every structure of UniProt Q64339
- Elsewhere: RCSB PDB 6YVA · PDBe 6YVA · UniProt P0DTC1 · UniProt Q64339
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