MolNFT v1 · #171120 · protein
Crystal structure of mhst in complex with L-isoleucine
6YU2 · Sodium-dependent transporter: “Crystal structure of mhst in complex with L-isoleucine”. X-ray diffraction, 2 ligands (ILE, NA), 6 pockets (best druggability 0.62). MolNFT v1 #171120 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6YU2
- Type
- protein
- Length
- 882 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sodium-dependent transporter
- UniProt
- A0A4Y7X244
- Ligands
- ILE, NA
- Pockets
- 6 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Sodium-dependent transporter | protein | 441 | 76% helix, 0% strand | A0A4Y7X244 |
Ligands and binding sites
- ILE · Isoleucine · ligand · 2 copies · chains A, B
- NA · Sodium ion · metal · 4 copies · chains A, B
- BOG · octyl beta-D-glucopyranoside · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.62 | 0.84 | 26 | empty |
| 2 | 180 | 0.61 | 0.83 | 28 | empty |
| 3 | 185 | 0.52 | 0.78 | 20 | empty |
| 4 | 144 | 0.46 | 0.77 | 19 | empty |
| 5 | 87 | 0.40 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 645 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6YU2 · Crystal structure of MhsT in complex with L-isoleucine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A4Y7X244
- Elsewhere: RCSB PDB 6YU2 · PDBe 6YU2 · UniProt A0A4Y7X244
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