MolNFT v1 · #171116 · protein
Cryo-EM structure of undecameric human CALHM6 in the presence of CA2+
6YTX · Calcium homeostasis modulator protein 6: “Cryo-EM structure of undecameric human CALHM6 in the presence of CA2+”. Electron microscopy, 20 pockets (best druggability 0.71). MolNFT v1 #171116 on GenesisL1: 3D structure, binding sites…
- PDB
- 6YTX
- Type
- protein
- Length
- 2,772 residues
- Chains
- 11
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium homeostasis modulator protein 6
- UniProt
- Q5R3K3
- Pockets
- 20 · best druggability 0.71
Structure
electron microscopy · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K | Calcium homeostasis modulator protein 6 | protein | 252 | 71% helix, 0% strand | Q5R3K3 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 686 | 0.71 | 0.78 | 76 | empty |
| 2 | 629 | 0.69 | 0.77 | 69 | empty |
| 3 | 520 | 0.69 | 0.78 | 46 | empty |
| 4 | 519 | 0.69 | 0.78 | 47 | empty |
| 5 | 351 | 0.68 | 0.81 | 45 | empty |
Interfaces
11 interfaces between chains.
- D–E · 2539 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 2516 Ų buried · 10 hydrogen bonds · protein-protein
- G–H · 2512 Ų buried · 10 hydrogen bonds · protein-protein
- A–K · 2510 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 2508 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 33 disulfide (disulfide).
Compared structures
- 6YTX · Cryo-EM structure of undecameric human CALHM6 in the presence of Ca2+ · the same entry in another collection · chain K against K, TM-score 1.00
- Q5R3K3 · AlphaFold monomer V2.0 prediction for calcium homeostasis modulator protein 6 (Q5R3K3) · a predicted model of the same protein · chain C against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5R3K3
- Elsewhere: RCSB PDB 6YTX · PDBe 6YTX · UniProt Q5R3K3
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