MolNFT v1 · #17108 · protein

Gafd (F17C-type) fimbrial adhesin from escherichia COLI

1OIO · Fimbrial lectin: “Gafd (F17C-type) fimbrial adhesin from escherichia COLI”. X-ray diffraction, 1 ligand (NAG), 1 pocket (best druggability 0.56). MolNFT v1 #17108 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1OIO
Type: protein
Length: 356 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fimbrial lectin
UniProt: Q47341
Ligands: NAG
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 60% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Fimbrial lectin	protein	178	2% helix, 60% strand	Q47341

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.56	0.78	24	empty

Interfaces

1 interface between chains.

A–B · 333 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1OIO · GafD (F17c-type) Fimbrial adhesin from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
Q47341 · AlphaFold monomer V2.0 prediction for F17G-G fimbrial adhesin (Q47341) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q47341
Elsewhere: RCSB PDB 1OIO · PDBe 1OIO · UniProt Q47341

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