MolNFT v1 · #171051 · protein

Structure of the chlamydomonas reinhardtii sas-6 coiled-coil domain, C2 crystal form

6YRL · Centriole protein: “Structure of the chlamydomonas reinhardtii sas-6 coiled-coil domain, C2 crystal form”. X-ray diffraction, 6 pockets (best druggability 0.45). MolNFT v1 #171051 on GenesisL1: 3D structure, binding sites and…

PDB: 6YRL
Type: protein
Length: 432 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centriole protein
UniProt: A9CQL4
Pockets: 6 · best druggability 0.45

Structure

x-ray diffraction · 4 distinct chains · 98% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Centriole protein	protein	108	98% helix, 0% strand	A9CQL4
B	Centriole protein	protein	108	97% helix, 0% strand	A9CQL4
C	Centriole protein	protein	105	97% helix, 0% strand	A9CQL4
D	Centriole protein	protein	111	98% helix, 0% strand	A9CQL4

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	205	0.45	0.73	30	empty
2	138	0.40	0.73	17	empty
3	167	0.40	0.72	18	empty
4	102	0.36	0.74	16	empty
5	115	0.34	0.72	18	empty

Interfaces

6 interfaces between chains.

A–D · 2821 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 2625 Å² buried · 15 hydrogen bonds · protein-protein
A–C · 1078 Å² buried · 20 hydrogen bonds · protein-protein
B–D · 369 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 101 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 modified, 2 disulfide (engineered, disulfide).

Compared structures

6YRL · Structure of the Chlamydomonas reinhardtii SAS-6 coiled-coil domain, C2 crystal form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9CQL4
Elsewhere: RCSB PDB 6YRL · PDBe 6YRL · UniProt A9CQL4

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