MolNFT v1 · #17081 · protein

Structure of caenorhabditis elegans ced-9

1OHU · Apoptosis regulator ced-9: “Structure of caenorhabditis elegans ced-9”. X-ray diffraction, 3 pockets (best druggability 0.60). MolNFT v1 #17081 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1OHU
Type: protein
Length: 333 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apoptosis regulator ced-9
UniProt: P41958
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apoptosis regulator ced-9	protein	165	70% helix, 0% strand	P41958
B	Apoptosis regulator ced-9	protein	168	71% helix, 0% strand	P41958

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	351	0.60	0.77	29	empty
2	53	0.34	0.78	11	empty
3	51	0.30	0.75	11	empty

Interfaces

1 interface between chains.

A–B · 304 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 18 modified (engineered).

Compared structures

1OHU · Structure of Caenorhabditis elegans CED-9 · the same entry in another collection · chain A against A, TM-score 1.00
P41958 · AlphaFold monomer V2.0 prediction for apoptosis regulator ced-9 (P41958) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41958
Elsewhere: RCSB PDB 1OHU · PDBe 1OHU · UniProt P41958

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