MolNFT v1 · #170797 · protein
Structure of the tfiiic subcomplex taua
6YJ6 · Transcription factor tau 131 kda subunit: “Structure of the tfiiic subcomplex taua”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #170797 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6YJ6
- Type
- protein
- Length
- 1,657 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor tau 131 kda subunit; Transcription factor tau 95 kda…
- UniProt
- P33339, P32367, Q12415
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 3 distinct chains · 48% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription factor tau 131 kda subunit | protein | 819 | 67% helix, 0% strand | P33339 |
| B | Transcription factor tau 95 kda SUBUNIT,TRANSCRIPTION factor tau 95 kda subunit | protein | 508 | 32% helix, 14% strand | P32367 |
| C | Transcription factor tau 55 kda subunit | protein | 330 | 25% helix, 21% strand | Q12415 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1189 | 0.81 | 0.82 | 117 | empty |
| 2 | 542 | 0.74 | 0.82 | 50 | empty |
| 3 | 456 | 0.73 | 0.83 | 40 | empty |
| 4 | 965 | 0.72 | 0.76 | 98 | empty |
| 5 | 692 | 0.71 | 0.78 | 79 | empty |
Interfaces
3 interfaces between chains.
- A–B · 6260 Ų buried · 62 hydrogen bonds · protein-protein
- B–C · 3210 Ų buried · 55 hydrogen bonds · protein-protein
- A–C · 858 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6YJ6 · Structure of the TFIIIC subcomplex tauA · the same entry in another collection · chain A against A, TM-score 1.00
- Q12415 · AlphaFold monomer V2.0 prediction for transcription factor tau 55 kda subunit (Q12415) · a predicted model of the same protein · chain C against A, TM-score 0.84
- P32367 · AlphaFold monomer V2.0 prediction for transcription factor tau 95 kda subunit (P32367) · a predicted model of the same protein · chain B against A, TM-score 0.59
- P33339 · AlphaFold monomer V2.0 prediction for transcription factor tau 131 kda subunit (P33339) · a predicted model of the same protein · chain A against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33339
- Every structure of UniProt P32367
- Every structure of UniProt Q12415
- Elsewhere: RCSB PDB 6YJ6 · PDBe 6YJ6 · UniProt P33339 · UniProt P32367 · UniProt Q12415
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