MolNFT v1 · #170687 · protein
Crystal structure of S287D,T291D MKK7 (MAP2K7), apo form
6YG0 · Dual specificity mitogen-activated protein kinase kinase 7: “Crystal structure of S287D,T291D MKK7 (MAP2K7), apo form”. X-ray diffraction, 3 pockets (best druggability 0.65). MolNFT v1 #170687 on GenesisL1: 3D structure, binding…
- PDB
- 6YG0
- Type
- protein
- Length
- 280 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity mitogen-activated protein kinase kinase 7
- EC
- 2.7.12.2
- UniProt
- O14733
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) | protein | 280 | 41% helix, 18% strand | O14733 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.65 | 0.88 | 32 | empty |
| 2 | 73 | 0.38 | 0.78 | 16 | empty |
| 3 | 74 | 0.33 | 0.75 | 16 | empty |
Compared structures
- 6YG0 · Crystal structure of S287D,T291D MKK7 (MAP2K7), apo form · the same entry in another collection · chain A against A, TM-score 1.00
- O14733 · AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14733
- Elsewhere: RCSB PDB 6YG0 · PDBe 6YG0 · UniProt O14733
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