MolNFT v1 · #170686 · protein

Crystal structure of MKK7 (MAP2K7), apo form

6YFZ · Dual specificity mitogen-activated protein kinase kinase 7: “Crystal structure of MKK7 (MAP2K7), apo form”. X-ray diffraction, 2 pockets (best druggability 0.64). MolNFT v1 #170686 on GenesisL1: 3D structure, binding sites and…

PDB: 6YFZ
Type: protein
Length: 296 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dual specificity mitogen-activated protein kinase kinase 7
EC: 2.7.12.2
UniProt: O14733
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2)	protein	296	41% helix, 17% strand	O14733

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	430	0.64	0.77	56	empty
2	52	0.28	0.74	14	empty

Compared structures

6YFZ · Crystal structure of MKK7 (MAP2K7), apo form · the same entry in another collection · chain A against A, TM-score 1.00
O14733 · AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase… · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14733
Elsewhere: RCSB PDB 6YFZ · PDBe 6YFZ · UniProt O14733

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