MolNFT v1 · #170545 · protein

Crystal structure of a parallel hexameric coiled coil cc-TYPE2-(TAID)5

6YAZ: “Crystal structure of a parallel hexameric coiled coil cc-TYPE2-(TAID)5”. X-ray diffraction, 4 pockets (best druggability 0.88). MolNFT v1 #170545 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6YAZ
Type: protein
Length: 433 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cc-TYPE2-(TAID)5
Pockets: 4 · best druggability 0.88

Structure

x-ray diffraction · 2 distinct chains · 89% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, F, G, H, I, J, K, L	Cc-TYPE2-(TAID)5	protein	36	89% helix, 0% strand	—
E	Cc-TYPE2-(TAID)5	protein	37	89% helix, 0% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	844	0.88	0.89	60	empty
2	910	0.88	0.88	60	empty
3	123	0.44	0.77	18	empty
4	105	0.42	0.77	20	empty

Interfaces

17 interfaces between chains.

I–J · 855 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 842 Å² buried · 4 hydrogen bonds · protein-protein
J–K · 836 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 831 Å² buried · 2 hydrogen bonds · protein-protein
K–L · 828 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6YAZ · Crystal structure of a parallel hexameric coiled coil CC-Type2-(TaId)5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6YAZ · PDBe 6YAZ

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