MolNFT v1 · #170111 · protein
Crystal structure of nemo in complex with ubv-lin
6XX0 · Inhibitor of kappa light polypeptide gene enhancer in B…: “Crystal structure of nemo in complex with ubv-lin”. X-ray diffraction, 1 pocket (best druggability 0.41). MolNFT v1 #170111 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6XX0
- Type
- protein
- Length
- 302 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inhibitor of kappa light polypeptide gene enhancer in B- cells, kinase gamma, isoform…
- UniProt
- D3DWY0
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 3 distinct chains · 68% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inhibitor of kappa light polypeptide gene enhancer in B- cells, kinase gamma, isoform CRA_B | protein | 75 | 91% helix, 0% strand | D3DWY0 |
| B | Inhibitor of kappa light polypeptide gene enhancer in B- cells, kinase gamma, isoform CRA_B | protein | 75 | 89% helix, 0% strand | D3DWY0 |
| C, D | Ubv-lin | protein | 76 | 24% helix, 37% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.41 | 0.77 | 27 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2039 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 669 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 596 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 151 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 136 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6XX0 · Crystal structure of NEMO in complex with Ubv-LIN · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D3DWY0
- Elsewhere: RCSB PDB 6XX0 · PDBe 6XX0 · UniProt D3DWY0
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