MolNFT v1 · #170078 · protein

Human myelin protein P2 mutant P38G, unliganded

6XVS · Myelin P2 protein: “Human myelin protein P2 mutant P38G, unliganded”. X-ray diffraction, 3 pockets (best druggability 0.85). MolNFT v1 #170078 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6XVS
Type: protein
Length: 266 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myelin P2 protein
UniProt: P02689
Pockets: 3 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Myelin P2 protein	protein	133	15% helix, 57% strand	P02689

Ligands and binding sites

GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	368	0.85	0.94	37	empty
2	382	0.83	0.92	40	empty
3	166	0.45	0.75	38	empty

Interfaces

1 interface between chains.

A–B · 585 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

6XVS · Human myelin protein P2 mutant P38G, unliganded · the same entry in another collection · chain A against A, TM-score 1.00
P02689 · AlphaFold monomer V2.0 prediction for myelin P2 protein (P02689) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02689
Elsewhere: RCSB PDB 6XVS · PDBe 6XVS · UniProt P02689

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