MolNFT v1 · #170069 · protein
Crystal structure of megabody mb-NB207-C7HOPQ_A12
6XVI · Outer membrane PROTEIN,OUTER membrane PROTEIN,MB-NB207…: “Crystal structure of megabody mb-NB207-C7HOPQ_A12”. X-ray diffraction, 14 pockets (best druggability 0.72). MolNFT v1 #170069 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6XVI
- Type
- protein
- Length
- 1,709 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Outer membrane PROTEIN,OUTER membrane PROTEIN,MB-NB207- C7HOPQ_A12
- UniProt
- B5Z8H1
- Pockets
- 14 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 45% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Outer membrane PROTEIN,OUTER membrane PROTEIN,MB-NB207- C7HOPQ_A12 | protein | 437 | 45% helix, 22% strand | B5Z8H1 |
| B | Outer membrane PROTEIN,OUTER membrane PROTEIN,MB-NB207- C7HOPQ_A12 | protein | 424 | 44% helix, 23% strand | B5Z8H1 |
| C | Outer membrane PROTEIN,OUTER membrane PROTEIN,MB-NB207- C7HOPQ_A12 | protein | 430 | 43% helix, 23% strand | B5Z8H1 |
| D | Outer membrane PROTEIN,OUTER membrane PROTEIN,MB-NB207- C7HOPQ_A12 | protein | 418 | 46% helix, 24% strand | B5Z8H1 |
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.72 | 0.76 | 94 | empty |
| 2 | 793 | 0.69 | 0.76 | 56 | empty |
| 3 | 676 | 0.67 | 0.76 | 59 | empty |
| 4 | 306 | 0.64 | 0.80 | 38 | empty |
| 5 | 414 | 0.62 | 0.77 | 40 | empty |
Interfaces
6 interfaces between chains.
- B–D · 1181 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 197 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 190 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 171 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 98 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 6XVI · Crystal structure of Megabody Mb-Nb207-c7HopQ_A12 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B5Z8H1
- Elsewhere: RCSB PDB 6XVI · PDBe 6XVI · UniProt B5Z8H1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.