MolNFT v1 · #169994 · protein
Subunits bbs 1,4,8,9,18 of the human bbsome complex
6XT9 · Bardet-biedl syndrome 1 protein: “Subunits bbs 1,4,8,9,18 of the human bbsome complex”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #169994 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6XT9
- Type
- protein
- Length
- 2,183 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bardet-biedl syndrome 1 protein; Bardet-biedl syndrome 4 protein; Tetratricopeptide…
- UniProt
- Q8NFJ9, Q96RK4, A0A0C4DGY3, Q3SYG4, A8MTZ0
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 5 distinct chains · 34% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bardet-biedl syndrome 1 protein | protein | 567 | 12% helix, 34% strand | Q8NFJ9 |
| D | Bardet-biedl syndrome 4 protein | protein | 396 | 67% helix, 0% strand | Q96RK4 |
| H | Tetratricopeptide repeat domain 8 isoform 2 | protein | 398 | 63% helix, 0% strand | A0A0C4DGY3 |
| I | Protein PTHB1 | protein | 767 | 19% helix, 23% strand | Q3SYG4 |
| J | Bbsome-interacting protein 1 | protein | 55 | 31% helix, 2% strand | A8MTZ0 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 966 | 0.86 | 0.87 | 99 | empty |
| 2 | 832 | 0.83 | 0.85 | 103 | empty |
| 3 | 919 | 0.79 | 0.81 | 66 | empty |
| 4 | 955 | 0.78 | 0.80 | 62 | empty |
| 5 | 1011 | 0.78 | 0.79 | 81 | empty |
Interfaces
9 interfaces between chains.
- A–D · 2482 Ų buried · 19 hydrogen bonds · protein-protein
- H–I · 2272 Ų buried · 16 hydrogen bonds · protein-protein
- A–I · 1985 Ų buried · 9 hydrogen bonds · protein-protein
- A–H · 1890 Ų buried · 4 hydrogen bonds · protein-protein
- H–J · 1711 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6XT9 · Subunits BBS 1,4,8,9,18 of the human BBSome complex · the same entry in another collection · chain J against J, TM-score 1.00
- Q96RK4 · AlphaFold monomer V2.0 prediction for bardet-biedl syndrome 4 protein (Q96RK4) · a predicted model of the same protein · chain D against A, TM-score 0.86
- Q3SYG4 · AlphaFold monomer V2.0 prediction for protein PTHB1 (Q3SYG4) · a predicted model of the same protein · chain I against A, TM-score 0.86
- Q8NFJ9 · AlphaFold monomer V2.0 prediction for bardet-biedl syndrome 1 protein (Q8NFJ9) · a predicted model of the same protein · chain A against A, TM-score 0.80
- A8MTZ0 · AlphaFold monomer V2.0 prediction for bbsome-interacting protein 1 (A8MTZ0) · a predicted model of the same protein · chain J against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NFJ9
- Every structure of UniProt Q96RK4
- Every structure of UniProt A0A0C4DGY3
- Every structure of UniProt Q3SYG4
- Every structure of UniProt A8MTZ0
- Elsewhere: RCSB PDB 6XT9 · PDBe 6XT9 · UniProt Q8NFJ9 · UniProt Q96RK4 · UniProt A0A0C4DGY3 · UniProt Q3SYG4 · UniProt A8MTZ0
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