MolNFT v1 · #169845 · protein

Cryoem structure of human presequence protease in open state

6XOU · Presequence protease, mitochondrial: “Cryoem structure of human presequence protease in open state”. Electron microscopy, 15 pockets (best druggability 0.72). MolNFT v1 #169845 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 6XOU
Type: protein
Length: 965 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Presequence protease, mitochondrial
EC: 3.4.24.-
UniProt: Q5JRX3
Pockets: 15 · best druggability 0.72

Structure

electron microscopy · 1 distinct chain · 46% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Presequence protease, mitochondrial (EC 3.4.24.-)	protein	965	46% helix, 20% strand	Q5JRX3

Pockets

15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	468	0.72	0.82	45	empty
2	71	0.64	0.92	15	empty
3	366	0.64	0.79	35	empty
4	134	0.64	0.87	35	empty
5	303	0.61	0.79	37	empty

Compared structures

6XOU · CryoEM structure of human presequence protease in open state · the same entry in another collection · chain A against A, TM-score 1.00
Q5JRX3 · AlphaFold monomer V2.0 prediction for presequence protease, mitochondrial (Q5JRX3) · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5JRX3
Elsewhere: RCSB PDB 6XOU · PDBe 6XOU · UniProt Q5JRX3

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