MolNFT v1 · #169789 · protein + RNA
Structure of the lactococcus lactis csm apo- CRISPR-CAS complex
6XN5 · CRISPR-associated protein CSM3: “Structure of the lactococcus lactis csm apo- CRISPR-CAS complex”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #169789 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6XN5
- Type
- protein + RNA
- Length
- 2,131 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR-associated protein CSM3; CRISPR-associated protein CAS10; CRISPR-associated…
- UniProt
- L0CEA3, L0CEJ3, L0CFH1, L0CG31
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 7 distinct chains · 33% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I, G | CRISPR-associated protein CSM3 | protein | 214 | 23% helix, 25% strand | L0CEA3 |
| F | CRISPR-associated protein CSM3 | protein | 207 | 26% helix, 32% strand | L0CEA3 |
| H | CRISPR-associated protein CSM3 | protein | 208 | 25% helix, 26% strand | L0CEA3 |
| A | CRISPR-associated protein CAS10 | protein | 735 | 50% helix, 12% strand | L0CEJ3 |
| B | CRISPR-associated protein CSM4 | protein | 282 | 18% helix, 30% strand | L0CFH1 |
| J | CRISPR-associated protein CSM5 | protein | 239 | 20% helix, 18% strand | L0CG31 |
| R | CRISPR RNA | rna | 32 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 585 | 0.79 | 0.85 | 69 | empty |
| 2 | 528 | 0.77 | 0.84 | 73 | empty |
| 3 | 50 | 0.73 | 0.98 | 14 | empty |
| 4 | 502 | 0.73 | 0.82 | 57 | empty |
| 5 | 82 | 0.73 | 0.96 | 20 | empty |
Interfaces
18 interfaces between chains.
- A–B · 1572 Ų buried · 21 hydrogen bonds · protein-protein
- B–R · 1547 Ų buried · 36 hydrogen bonds · protein-nucleic
- H–G · 1369 Ų buried · 16 hydrogen bonds · protein-protein
- F–B · 1368 Ų buried · 17 hydrogen bonds · protein-protein
- I–H · 1353 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6XN5 · Structure of the Lactococcus lactis Csm Apo- CRISPR-Cas Complex · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L0CEA3
- Every structure of UniProt L0CEJ3
- Every structure of UniProt L0CFH1
- Every structure of UniProt L0CG31
- Elsewhere: RCSB PDB 6XN5 · PDBe 6XN5 · UniProt L0CEA3 · UniProt L0CEJ3 · UniProt L0CFH1 · UniProt L0CG31
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