MolNFT v1 · #169648 · protein

Crystal structure of CDC15 F-bar domain from schizosaccharomyces pombe

6XJ1 · Cell division control protein 15: “Crystal structure of CDC15 F-bar domain from schizosaccharomyces pombe”. X-ray diffraction, 7 pockets (best druggability 0.70). MolNFT v1 #169648 on GenesisL1: 3D structure, binding sites and…

PDB: 6XJ1
Type: protein
Length: 543 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division control protein 15
UniProt: Q09822
Pockets: 7 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division control protein 15	protein	266	75% helix, 0% strand	Q09822
B	Cell division control protein 15	protein	277	77% helix, 0% strand	Q09822

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	315	0.70	0.84	29	empty
2	203	0.67	0.86	31	empty
3	121	0.57	0.83	23	empty
4	207	0.53	0.77	24	empty
5	77	0.37	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 4441 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

6XJ1 · Crystal Structure of CDC15 F-BAR Domain from Schizosaccharomyces pombe · the same entry in another collection · chain A against A, TM-score 1.00
Q09822 · AlphaFold monomer V2.0 prediction for cell division control protein 15 (Q09822) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q09822
Elsewhere: RCSB PDB 6XJ1 · PDBe 6XJ1 · UniProt Q09822

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