MolNFT v1 · #16964 · protein
Structure of acetylcholine receptor pore from electron images
1OED · Acetylcholine receptor subunit alpha: “Structure of acetylcholine receptor pore from electron images”. Electron microscopy, 8 pockets (best druggability 0.86). MolNFT v1 #16964 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1OED
- Type
- protein
- Length
- 636 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetylcholine receptor subunit alpha; Acetylcholine receptor beta subunit; Acetylcholine…
- UniProt
- P02711, Q6S3I0, Q6S3H8, Q6S3H9
- Pockets
- 8 · best druggability 0.86
Structure
electron microscopy · 4 distinct chains · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Acetylcholine receptor subunit alpha | protein | 127 | 91% helix, 0% strand | P02711 |
| B | Acetylcholine receptor beta subunit | protein | 127 | 86% helix, 0% strand | Q6S3I0 |
| C | Acetylcholine receptor delta subunit | protein | 127 | 87% helix, 0% strand | Q6S3H8 |
| E | Acetylcholine receptor gamma subunit | protein | 128 | 85% helix, 0% strand | Q6S3H9 |
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1074 | 0.86 | 0.86 | 115 | empty |
| 2 | 361 | 0.84 | 0.92 | 54 | empty |
| 3 | 429 | 0.82 | 0.89 | 42 | empty |
| 4 | 1103 | 0.81 | 0.82 | 93 | empty |
| 5 | 178 | 0.75 | 0.90 | 36 | empty |
Interfaces
5 interfaces between chains.
- D–E · 860 Ų buried · 2 hydrogen bonds · protein-protein
- A–E · 791 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 783 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 691 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 673 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1OED · Structure of acetylcholine receptor pore from electron images · the same entry in another collection · chain B against B, TM-score 1.00
- P02711 · AlphaFold monomer V2.0 prediction for acetylcholine receptor subunit alpha (P02711) · a predicted model of the same protein · chain A against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02711
- Every structure of UniProt Q6S3I0
- Every structure of UniProt Q6S3H8
- Every structure of UniProt Q6S3H9
- Elsewhere: RCSB PDB 1OED · PDBe 1OED · UniProt P02711 · UniProt Q6S3I0 · UniProt Q6S3H8 · UniProt Q6S3H9
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