MolNFT v1 · #169570 · protein + DNA
ISCTH4 transposase, pre-cleaved complex, pcc
6XG8 · Mutator family transposase: “ISCTH4 transposase, pre-cleaved complex, pcc”. X-ray diffraction, 13 pockets (best druggability 0.77). MolNFT v1 #169570 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6XG8
- Type
- protein + DNA
- Length
- 804 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mutator family transposase; DNA (26-mer)
- UniProt
- A3DBR0
- Pockets
- 13 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mutator family transposase | protein | 401 | 48% helix, 17% strand | A3DBR0 |
| B | Mutator family transposase | protein | 351 | 57% helix, 13% strand | A3DBR0 |
| D | DNA (26-mer) | dna | 26 | — | — |
| E | DNA (26-mer) | dna | 26 | — | — |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1160 | 0.77 | 0.79 | 101 | empty |
| 2 | 53 | 0.74 | 0.99 | 18 | empty |
| 3 | 134 | 0.70 | 0.91 | 19 | empty |
| 4 | 213 | 0.65 | 0.83 | 34 | empty |
| 5 | 321 | 0.58 | 0.77 | 34 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2220 Ų buried · 15 hydrogen bonds · protein-protein
- A–E · 1274 Ų buried · 31 hydrogen bonds · protein-nucleic
- A–D · 1163 Ų buried · 18 hydrogen bonds · protein-nucleic
- D–E · 1130 Ų buried · 80 hydrogen bonds · nucleic-nucleic
- B–E · 405 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 6XG8 · ISCth4 transposase, pre-cleaved complex, PCC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3DBR0
- Elsewhere: RCSB PDB 6XG8 · PDBe 6XG8 · UniProt A3DBR0
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