MolNFT v1 · #169531 · protein
Nesprin-1G (AA2070-2200)-FHOD1(AA1-339) complex, H. sapiens
6XF2: “Nesprin-1G (AA2070-2200)-FHOD1(AA1-339) complex, H. sapiens”. X-ray diffraction, 8 pockets (best druggability 0.78). MolNFT v1 #169531 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6XF2
- Type
- protein
- Length
- 869 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nesprin-1; FH1/FH2 domain-containing protein 1
- UniProt
- Q8NF91, Q9Y613
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 73% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nesprin-1 | protein | 118 | 86% helix, 0% strand | Q8NF91 |
| B, D | FH1/FH2 domain-containing protein 1 | protein | 321 | 62% helix, 8% strand | Q9Y613 |
| C | Nesprin-1 | protein | 109 | 92% helix, 0% strand | Q8NF91 |
Pockets
8 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 451 | 0.78 | 0.86 | 53 | empty |
| 2 | 461 | 0.76 | 0.84 | 55 | empty |
| 3 | 74 | 0.73 | 0.96 | 20 | empty |
| 4 | 72 | 0.72 | 0.95 | 21 | empty |
| 5 | 878 | 0.70 | 0.75 | 83 | empty |
Interfaces
2 interfaces between chains.
- C–D · 419 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 401 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6XF2 · Nesprin-1G (aa2070-2200)-FHOD1(aa1-339) complex, H. sapiens · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y613 · AlphaFold monomer V2.0 prediction for FH1/FH2 domain-containing protein 1 (Q9Y613) · a predicted model of the same protein · chain D against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NF91
- Every structure of UniProt Q9Y613
- Elsewhere: RCSB PDB 6XF2 · PDBe 6XF2 · UniProt Q8NF91 · UniProt Q9Y613
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