MolNFT v1 · #169501 · protein
Structure of human dispatched-1 (DISP1)
6XE6 · Protein dispatched homolog 1: “Structure of human dispatched-1 (DISP1)”. Electron microscopy, 2 ligands (Y01, NAG), 12 pockets (best druggability 0.79). MolNFT v1 #169501 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6XE6
- Type
- protein
- Length
- 826 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein dispatched homolog 1
- UniProt
- Q96F81
- Ligands
- Y01, NAG
- Pockets
- 12 · best druggability 0.79
Structure
electron microscopy · 1 distinct chain · 56% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein dispatched homolog 1 | protein | 826 | 56% helix, 1% strand | Q96F81 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 5 copies · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1062 | 0.79 | 0.81 | 122 | empty |
| 2 | 209 | 0.79 | 0.93 | 51 | empty |
| 3 | 517 | 0.71 | 0.80 | 55 | empty |
| 4 | 319 | 0.68 | 0.82 | 25 | Y01 |
| 5 | 216 | 0.52 | 0.76 | 23 | empty |
Modifications
Observed in the structure: 1 disulfide, 1 glycan (disulfide, glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96F81
- Elsewhere: RCSB PDB 6XE6 · PDBe 6XE6 · UniProt Q96F81
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