MolNFT v1 · #169291 · protein
BRD4 bromodomain 1 in complex with multi-action inhibitor SF2523P
6X7D: “BRD4 bromodomain 1 in complex with multi-action inhibitor SF2523P”. X-ray diffraction, 1 ligand (UT4). MolNFT v1 #169291 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6X7D
- Type
- protein
- Length
- 252 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O60885
- Ligands
- UT4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 124 | — | O60885 |
| B | — | protein | 128 | — | O60885 |
Ligands and binding sites
- UT4 · 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-7-one · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6X7D · BRD4 Bromodomain 1 in complex with multi-action inhibitor SF2523P · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 6X7D · PDBe 6X7D · UniProt O60885
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