MolNFT v1 · #169104 · protein
Structure of MZT2/GCP-nhd and CDK5RAP2 at position 13 of the gamma- turc
6X0V · Mitotic-spindle organizing protein 2A: “Structure of MZT2/GCP-nhd and CDK5RAP2 at position 13 of the gamma- turc”. Electron microscopy, 2 pockets (best druggability 0.72). MolNFT v1 #169104 on GenesisL1: 3D structure, binding sites…
- PDB
- 6X0V
- Type
- protein
- Length
- 211 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic-spindle organizing protein 2A; Gamma-tubulin complex component 2; Centrosome…
- UniProt
- Q6P582, Q9BSJ2, Q66GT8
- Pockets
- 2 · best druggability 0.72
Structure
electron microscopy · 4 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Mitotic-spindle organizing protein 2A | protein | 46 | 72% helix, 0% strand | Q6P582 |
| F | Gamma-tubulin complex component 2 | protein | 95 | 58% helix, 0% strand | Q9BSJ2 |
| G | Centrosome protein CEP215 | protein | 35 | 80% helix, 0% strand | Q66GT8 |
| H | Centrosome protein CEP215 | protein | 35 | 83% helix, 0% strand | Q66GT8 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1169 | 0.72 | 0.76 | 97 | empty |
| 2 | 55 | 0.25 | 0.73 | 17 | empty |
Interfaces
3 interfaces between chains.
- G–H · 924 Ų buried · 3 hydrogen bonds · protein-protein
- E–F · 651 Ų buried · 0 hydrogen bonds · protein-protein
- F–H · 314 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6X0V · Structure of MZT2/GCP-NHD and CDK5Rap2 at position 13 of the gamma-TuRC · the same entry in another collection · chain E against E, TM-score 1.00
- Q6P582 · AlphaFold monomer V2.0 prediction for mitotic-spindle organizing protein 2A (Q6P582) · a predicted model of the same protein · chain E against A, TM-score 0.79
- Q9BSJ2 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 2 (Q9BSJ2) · a predicted model of the same protein · chain F against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P582
- Every structure of UniProt Q9BSJ2
- Every structure of UniProt Q66GT8
- Elsewhere: RCSB PDB 6X0V · PDBe 6X0V · UniProt Q6P582 · UniProt Q9BSJ2 · UniProt Q66GT8
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