MolNFT v1 · #168907 · protein
Mitochondrial SAM complex - high resolution monomer in detergent
6WUT · SAM35: “Mitochondrial SAM complex - high resolution monomer in detergent”. Electron microscopy, 14 pockets (best druggability 0.74). MolNFT v1 #168907 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WUT
- Type
- protein
- Length
- 1,087 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SAM35; BAC_SURFACE_AG domain-containing protein; TOM37 domain-containing protein
- UniProt
- G2QAT9, G2QFF9, G2Q6R7
- Pockets
- 14 · best druggability 0.74
Structure
electron microscopy · 3 distinct chains · 34% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SAM35 | protein | 296 | 49% helix, 6% strand | G2QAT9 |
| B | BAC_SURFACE_AG domain-containing protein | protein | 443 | 9% helix, 38% strand | G2QFF9 |
| C | TOM37 domain-containing protein | protein | 348 | 52% helix, 7% strand | G2Q6R7 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.74 | 0.94 | 33 | empty |
| 2 | 1155 | 0.74 | 0.77 | 116 | empty |
| 3 | 1051 | 0.70 | 0.74 | 79 | empty |
| 4 | 367 | 0.69 | 0.82 | 49 | empty |
| 5 | 141 | 0.63 | 0.86 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–C · 2082 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1981 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 967 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6WUT · Mitochondrial SAM complex - high resolution monomer in detergent · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G2QAT9
- Every structure of UniProt G2QFF9
- Every structure of UniProt G2Q6R7
- Elsewhere: RCSB PDB 6WUT · PDBe 6WUT · UniProt G2QAT9 · UniProt G2QFF9 · UniProt G2Q6R7
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