MolNFT v1 · #168901 · protein
Mitochondrial SAM complex - dimer 2 in detergent
6WUM · SAM35: “Mitochondrial SAM complex - dimer 2 in detergent”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #168901 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WUM
- Type
- protein
- Length
- 2,172 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SAM35; TOM37 domain-containing protein; BAC_SURFACE_AG domain-containing protein
- UniProt
- G2QAT9, G2Q6R7, G2QFF9
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 32% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, A | SAM35 | protein | 295 | 44% helix, 4% strand | G2QAT9 |
| b, C | TOM37 domain-containing protein | protein | 346 | 52% helix, 4% strand | G2Q6R7 |
| a, B | BAC_SURFACE_AG domain-containing protein | protein | 445 | 9% helix, 31% strand | G2QFF9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1003 | 0.79 | 0.80 | 110 | empty |
| 2 | 1027 | 0.78 | 0.80 | 120 | empty |
| 3 | 129 | 0.76 | 0.95 | 38 | empty |
| 4 | 125 | 0.76 | 0.95 | 31 | empty |
| 5 | 1091 | 0.75 | 0.77 | 70 | empty |
Interfaces
12 interfaces between chains.
- A–C · 2112 Ų buried · 12 hydrogen bonds · protein-protein
- E–b · 2102 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 2040 Ų buried · 26 hydrogen bonds · protein-protein
- E–a · 2019 Ų buried · 25 hydrogen bonds · protein-protein
- b–C · 1231 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6WUM · Mitochondrial SAM complex - dimer 2 in detergent · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G2QAT9
- Every structure of UniProt G2Q6R7
- Every structure of UniProt G2QFF9
- Elsewhere: RCSB PDB 6WUM · PDBe 6WUM · UniProt G2QAT9 · UniProt G2Q6R7 · UniProt G2QFF9
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