MolNFT v1 · #168848 · protein
Structure of a bacterial sting receptor from capnocytophaga granulosa
6WT5: “Structure of a bacterial sting receptor from capnocytophaga granulosa”. X-ray diffraction, 4 pockets (best druggability 0.65). MolNFT v1 #168848 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WT5
- Type
- protein
- Length
- 573 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacterial sting
- UniProt
- A0A381HAP5
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 51% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bacterial sting | protein | 144 | 51% helix, 24% strand | A0A381HAP5 |
| B | Bacterial sting | protein | 143 | 52% helix, 22% strand | A0A381HAP5 |
| C | Bacterial sting | protein | 151 | 46% helix, 27% strand | A0A381HAP5 |
| D | Bacterial sting | protein | 135 | 53% helix, 18% strand | A0A381HAP5 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 773 | 0.65 | 0.74 | 65 | empty |
| 2 | 314 | 0.54 | 0.75 | 43 | empty |
| 3 | 212 | 0.44 | 0.73 | 35 | empty |
| 4 | 51 | 0.24 | 0.73 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1427 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1332 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 24 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 6WT5 · Structure of a bacterial STING receptor from Capnocytophaga granulosa · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A381HAP5
- Elsewhere: RCSB PDB 6WT5 · PDBe 6WT5 · UniProt A0A381HAP5
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