MolNFT v1 · #168707 · protein

Structure of the broadly neutralizing antibody HC1AM

6WOR · Fab HC1AM heavy chain: “Structure of the broadly neutralizing antibody HC1AM”. X-ray diffraction, 5 pockets (best druggability 0.64). MolNFT v1 #168707 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6WOR
Type: protein
Length: 426 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab HC1AM heavy chain; Fab HC1AM light chain
Pockets: 5 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab HC1AM heavy chain	protein	214	7% helix, 51% strand	—
L	Fab HC1AM light chain	protein	212	7% helix, 50% strand	—

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	101	0.64	0.88	22	empty
2	474	0.58	0.74	54	empty
3	124	0.38	0.74	20	empty
4	94	0.36	0.75	24	empty
5	58	0.27	0.73	24	empty

Interfaces

1 interface between chains.

H–L · 1824 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6WOR · Structure of the broadly neutralizing antibody HC1AM · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6WOR · PDBe 6WOR

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