MolNFT v1 · #168596 · protein

INTS3 C-terminal domain

6WLG · Integrator complex subunit 3: “INTS3 C-terminal domain”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #168596 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6WLG
Type: protein
Length: 707 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrator complex subunit 3
UniProt: Q68E01
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrator complex subunit 3	protein	361	65% helix, 0% strand	Q68E01
B	Integrator complex subunit 3	protein	346	66% helix, 0% strand	Q68E01

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1036	0.74	0.77	92	empty
2	302	0.71	0.84	48	empty
3	158	0.69	0.88	28	empty
4	82	0.42	0.79	16	empty

Interfaces

1 interface between chains.

A–B · 476 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6WLG · Ints3 C-terminal Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q68E01 · AlphaFold monomer V2.0 prediction for integrator complex subunit 3 (Q68E01) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q68E01
Elsewhere: RCSB PDB 6WLG · PDBe 6WLG · UniProt Q68E01

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.