MolNFT v1 · #168592 · protein
Structure of homotrimeric poplar cellulose synthase isoform 8
6WLB: “Structure of homotrimeric poplar cellulose synthase isoform 8”. Electron microscopy, 1 ligand (BGC), 20 pockets (best druggability 0.86). MolNFT v1 #168592 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WLB
- Type
- protein
- Length
- 2,160 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellulose synthase
- EC
- 2.4.1.12
- UniProt
- Q6J8X0
- Ligands
- BGC
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 53% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B | Cellulose synthase (EC 2.4.1.12) | protein | 720 | 53% helix, 9% strand | Q6J8X0 |
Ligands and binding sites
- BGC · beta-D-glucopyranose · sugar · 15 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 755 | 0.86 | 0.89 | 102 | BGC |
| 2 | 758 | 0.86 | 0.89 | 84 | BGC |
| 3 | 384 | 0.81 | 0.89 | 49 | BGC |
| 4 | 179 | 0.74 | 0.90 | 37 | BGC |
| 5 | 201 | 0.74 | 0.89 | 41 | BGC |
Interfaces
3 interfaces between chains.
- C–B · 1235 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 1229 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 1218 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6WLB · Structure of homotrimeric poplar cellulose synthase isoform 8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6J8X0
- Elsewhere: RCSB PDB 6WLB · PDBe 6WLB · UniProt Q6J8X0
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