MolNFT v1 · #168574 · protein

Fab fragment of anti-human LAG3 antibody (22D2)

6WKM · 22D2 Fab heavy chain: “Fab fragment of anti-human LAG3 antibody (22D2)”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #168574 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6WKM
Type: protein
Length: 437 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 22D2 Fab heavy chain; 22D2 Fab light chain
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	22D2 Fab heavy chain	protein	219	7% helix, 51% strand	—
L	22D2 Fab light chain	protein	218	6% helix, 51% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	454	0.61	0.76	45	empty
2	167	0.51	0.78	31	empty
3	70	0.29	0.73	16	empty
4	58	0.29	0.74	14	empty

Interfaces

1 interface between chains.

H–L · 1813 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6WKM · Fab Fragment of Anti-human LAG3 antibody (22D2) · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6WKM · PDBe 6WKM

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