MolNFT v1 · #168557 · protein
Crystal structure of gdx-clo from small multidrug resistance family of transporters
6WK5 · Multidrug resistance protein, smr family: “Crystal structure of gdx-clo from small multidrug resistance family of transporters”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #168557 on GenesisL1: 3D structure…
- PDB
- 6WK5
- Type
- protein
- Length
- 384 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance protein, smr family; L10 monobody
- UniProt
- U2EQ00
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Multidrug resistance protein, smr family | protein | 104 | 85% helix, 1% strand | U2EQ00 |
| C | L10 monobody | protein | 89 | 0% helix, 52% strand | — |
| D | L10 monobody | protein | 87 | 0% helix, 55% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 483 | 0.73 | 0.82 | 37 | empty |
| 2 | 56 | 0.31 | 0.75 | 14 | empty |
Interfaces
3 interfaces between chains.
- B–A · 1359 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 398 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 373 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 6WK5 · Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt U2EQ00
- Elsewhere: RCSB PDB 6WK5 · PDBe 6WK5 · UniProt U2EQ00
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