MolNFT v1 · #168494 · protein

Next generation monomeric IGG4 Fc

6WIB · Immunoglobulin heavy constant gamma 4: “Next generation monomeric IGG4 Fc”. X-ray diffraction, 5 ligands (NAG, MAN, BMA). MolNFT v1 #168494 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6WIB
Type: protein
Length: 210 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Immunoglobulin heavy constant gamma 4
UniProt: P01861
Ligands: NAG, MAN, BMA, FUC, ZN

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Immunoglobulin heavy constant gamma 4	protein	210	10% helix, 47% strand	P01861

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A
BMA · beta-D-mannopyranose · sugar · chains A
FUC · alpha-L-fucopyranose · sugar · chains A
ZN · Zinc ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 3 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

6WIB · Next generation monomeric IgG4 Fc · the same entry in another collection · chain A against A, TM-score 1.00
P01861 · AlphaFold monomer V2.0 prediction for immunoglobulin heavy constant gamma 4 (P01861) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01861
Elsewhere: RCSB PDB 6WIB · PDBe 6WIB · UniProt P01861

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