MolNFT v1 · #168410 · protein
Crystal structure of FAB364 in complex with NPNA2 peptide from circumsporozoite protein
6WFW · Immunoglobulin G-binding protein G: “Crystal structure of FAB364 in complex with NPNA2 peptide from circumsporozoite protein”. X-ray diffraction, 6 pockets (best druggability 0.49). MolNFT v1 #168410 on GenesisL1: 3D structure…
- PDB
- 6WFW
- Type
- protein
- Length
- 491 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin G-binding protein G; FAB364 heavy chain; FAB364 light chain; NPNA2 peptide
- UniProt
- P19909
- Pockets
- 6 · best druggability 0.49
Structure
x-ray diffraction · 4 distinct chains · 9% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Immunoglobulin G-binding protein G | protein | 60 | 23% helix, 48% strand | P19909 |
| H | FAB364 heavy chain | protein | 212 | 8% helix, 53% strand | — |
| L | FAB364 light chain | protein | 211 | 6% helix, 51% strand | — |
| P | NPNA2 peptide | protein | 8 | 0% helix, 0% strand | — |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 241 | 0.49 | 0.75 | 34 | empty |
| 2 | 141 | 0.42 | 0.75 | 28 | empty |
| 3 | 102 | 0.38 | 0.75 | 24 | empty |
| 4 | 74 | 0.34 | 0.75 | 16 | empty |
| 5 | 82 | 0.33 | 0.74 | 21 | empty |
Interfaces
5 interfaces between chains.
- H–L · 1708 Ų buried · 18 hydrogen bonds · protein-protein
- G–H · 537 Ų buried · 15 hydrogen bonds · protein-protein
- H–P · 418 Ų buried · 7 hydrogen bonds · protein-protein
- L–P · 144 Ų buried · 5 hydrogen bonds · protein-protein
- G–L · 128 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6WFW · Crystal structure of Fab364 in complex with NPNA2 peptide from circumsporozoite protein · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19909
- Elsewhere: RCSB PDB 6WFW · PDBe 6WFW · UniProt P19909
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.