MolNFT v1 · #168295 · protein
High resolution crystal structure of MRECK(CC4) in fusion with engineered mbp
6WBJ · Maltodextrin-binding PROTEIN,REVERSION-inducing cysteine…: “High resolution crystal structure of MRECK(CC4) in fusion with engineered mbp”. X-ray diffraction, 3 ligands (GLC, ZN, SO4), 3 pockets (best druggability 0.71). MolNFT v1…
- PDB
- 6WBJ
- Type
- protein
- Length
- 432 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltodextrin-binding PROTEIN,REVERSION-inducing cysteine- rich protein with kazal motifs…
- UniProt
- A0A376KDN7, Q9Z0J1
- Ligands
- GLC, ZN, SO4
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltodextrin-binding PROTEIN,REVERSION-inducing cysteine- rich protein with kazal motifs fusion | protein | 432 | 49% helix, 18% strand | A0A376KDN7, Q9Z0J1 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- ZN · Zinc ion · metal · 2 copies · chains A
- SO4 · Sulfate ion · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.71 | 0.83 | 31 | GLC |
| 2 | 381 | 0.57 | 0.75 | 47 | empty |
| 3 | 245 | 0.54 | 0.77 | 28 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6WBJ · High resolution crystal structure of mRECK(CC4) in fusion with engineered MBP · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z0J1 · AlphaFold monomer V2.0 prediction for reversion-inducing cysteine- rich protein with… · a predicted model of the same protein · chain A against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A376KDN7
- Every structure of UniProt Q9Z0J1
- Elsewhere: RCSB PDB 6WBJ · PDBe 6WBJ · UniProt A0A376KDN7 · UniProt Q9Z0J1
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