MolNFT v1 · #168245 · protein

Dimeric form of the trans-stabilized hemolysin II C-terminal domain

6WA1: “Dimeric form of the trans-stabilized hemolysin II C-terminal domain”. Solution nmr, 2 pockets (best druggability 0.82). MolNFT v1 #168245 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6WA1
Type: protein
Length: 188 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hemolysin II
UniProt: Q81AN8
Pockets: 2 · best druggability 0.82

Structure

solution nmr · 1 distinct chain · 27% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hemolysin II	protein	94	27% helix, 33% strand	Q81AN8

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	259	0.82	0.93	35	empty
2	250	0.79	0.92	37	empty

Interfaces

1 interface between chains.

A–B · 968 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6WA1 · Dimeric form of the trans-stabilized Hemolysin II C-terminal domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q81AN8
Elsewhere: RCSB PDB 6WA1 · PDBe 6WA1 · UniProt Q81AN8

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