MolNFT v1 · #16820 · protein

Axh domain of human spinocerebellar ataxin-1

1OA8: “Axh domain of human spinocerebellar ataxin-1”. X-ray diffraction, 1 ligand (NA), 12 pockets (best druggability 0.77). MolNFT v1 #16820 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1OA8
Type: protein
Length: 518 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ataxin-1
UniProt: P54253
Ligands: NA
Pockets: 12 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 20% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ataxin-1	protein	128	19% helix, 41% strand	P54253
C	Ataxin-1	protein	129	21% helix, 41% strand	P54253
D	Ataxin-1	protein	133	20% helix, 38% strand	P54253

Ligands and binding sites

NA · Sodium ion · metal · 3 copies · chains A, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.77	0.98	18	empty
2	80	0.75	0.97	26	empty
3	65	0.74	0.98	19	empty
4	458	0.69	0.80	35	empty
5	366	0.67	0.80	59	empty

Interfaces

3 interfaces between chains.

C–D · 1665 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 1595 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 842 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

1OA8 · AXH domain of human spinocerebellar ataxin-1 · the same entry in another collection · chain D against D, TM-score 1.00
P54253 · AlphaFold monomer V2.0 prediction for ataxin-1 (P54253) · a predicted model of the same protein · chain C against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P54253
Elsewhere: RCSB PDB 1OA8 · PDBe 1OA8 · UniProt P54253

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